Spravato (Esketamine). CIII Nasal Spray | Maryland Spravato & TMS Center

At Maryland Spravato & TMS Center, we offer Spravato® (esketamine) CIII nasal spray as an advanced option for adults living with Treatment-Resistant Depression (TRD) or Major Depressive Disorder (MDD) with acute suicidal thoughts or behaviors. Administered under medical supervision in our certified clinic, Spravato® provides rapid-acting relief for individuals who need a breakthrough in care.

What is Spravato?

Spravato is a prescription nasal spray containing esketamine, a derivative of ketamine. It is FDA-approved for two specific indications:

Treatment-Resistant Depression (TRD): For adults who have not responded to at least two antidepressants taken at adequate dose and duration. Spravato is used in conjunction with an oral antidepressant.
Major Depressive Disorder with Acute Suicidal Thoughts or Actions: For adults in crisis who require immediate symptom relief. Spravato® is used alongside an oral antidepressant to stabilize mood rapidly.

Who is Spravato For?

Spravato® may be appropriate for adults who meet the following criteria:

Have a diagnosis of TRD and have not improved with at least two antidepressants.

Limitations of Use:

Spravato® is not indicated for use in children.
Hospitalization may still be necessary even if rapid symptom relief is observed.

How Does Spravato Work Differently?

Unlike traditional antidepressants that affect serotonin, dopamine, or norepinephrine, Spravato® works on the NMDA receptor—a different pathway involved in glutamate signaling. This is believed to restore synaptic connections in the brain, offering faster symptom relief for individuals with difficult-to-treat depression.

What to Expect During Spravato Treatment

Understanding the treatment process can help you feel more confident and prepared. At Maryland Spravato & TMS Center, your comfort and safety are our top priorities.

From your first session to long-term care, we guide you through every phase—including pre-treatment preparation, in-clinic administration, and post-treatment monitoring.

Topics covered include:

How to prepare before your session
What happens during your in-clinic treatment
Side effects and safety monitoring
Post-treatment care instructions
The full treatment schedule

Rapid Symptom Relief: Many patients report improvement within 24 hours of their first dose.
Innovative Mechanism: Provides an alternative for those unresponsive to standard antidepressan

Take the First Step Toward Relief — Schedule Your Spravato® Consultation Today

Call (443) 713-8643 or Book Online to speak with our clinical intake team and find out if you’re a candidate for Spravato® treatment.

Book an Appointment

Book an Appointment

Book an Appointment

Spravato (Esketamine). CIII Nasal Spray | Maryland Spravato & TMS Center

What is Spravato?

Who is Spravato For?

How Does Spravato Work Differently?

What to Expect During Spravato Treatment

Potential Benefits of Spravato®

Take the First Step Toward Relief — Schedule Your Spravato® Consultation Today

📃Pages

🧠Services

🕛Hours: